Quantitative assessment of cell fate decision between autophagy and apoptosis
نویسندگان
چکیده
منابع مشابه
The cellular decision between apoptosis and autophagy
Apoptosis and autophagy are important molecular processes that maintain organismal and cellular homeostasis, respectively. While apoptosis fulfills its role through dismantling damaged or unwanted cells, autophagy maintains cellular homeostasis through recycling selective intracellular organelles and molecules. Yet in some conditions, autophagy can lead to cell death. Apoptosis and autophagy ca...
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Autophagy pathway has been one of the hot topics during the last decade. From a general notion about its cellular role, autophagy becomes a more sophisticated phenomenon with significant implications in cellular homeostasis. Consequently, autophagy represents an emerging new factor in human diseases. Despite its general task, the bulk degradation of cellular constituents during starvation setti...
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Objective(s): Various microRNAs (miRNAs) are expressed during development of mammalian cells, when they aid in modulating gene expression by mediating mRNA transcript cleavage and/or regulation of translation rate. miR-191 and miR-451 have been shown to be critical regulators of hematopoiesis and have important roles in the induction of erythroid fate decision. So, the aim of this study is inve...
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From bacteria to mammals, individual cells from an isogenic population are able to assume roles resulting in phenotypic heterogeneity. The mechanisms used to make these cell fate decisions range from highly deterministic to essentially random. This wide range of behaviour springs from the interplay of intracellular molecular kinetics, the topologies of underlying gene regulator networks, epigen...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-18001-w